Osteoporosis Therapy: Bone Modeling during Growth and Aging
نویسندگان
چکیده
منابع مشابه
Osteoporosis Therapy: Bone Modeling during Growth and Aging
Remodeling-based bone resorption and formation are coupled on the same surface and contribute to calcium homeostasis, while modeling-based bone formation and resorption occur on different surfaces, such as during growth, to change skeletal shape; of importance, the aging skeleton can also include bone modeling (1, 2). The primary determinant of bone modeling is elastic deformation (strain) of t...
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BACKGROUND Rapamycin is an effective immunosuppressant widely used to maintain the renal allograft in pediatric patients. Linear growth may be adversely affected in young children since rapamycin has potent anti-proliferative and anti-angiogenic properties. METHODS Weanling three week old rats were given rapamycin at 2.5 mg/kg daily by gavage for 2 or 4 weeks and compared to a Control group g...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2017
ISSN: 1664-2392
DOI: 10.3389/fendo.2017.00046